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Binding: HardcoverDewey Decimal Number: 616.151 EAN: 9780127729404 Edition: 1 ISBN: 0127729402 Label: Academic Press Manufacturer: Academic Press Number Of Items: 1 Number Of Pages: 296 Publication Date: 2000-02 Publisher: Academic Press Studio: Academic Press Alternate Versions: Click to Display Browse for similar items by category: Click to Display Editorial Review: Product Description: Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins. This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins. Key Features * Outlines the chemical features of PNH * Explains the mechanism of hemolysis * Includes work on the biochemistry of glycophosphoinositol anchors * Contains descriptions of the chemistry and biophysics of GPI-anchored proteins Average Rating:
 Rating: - Hematology Must HaveAn insightful look into the link between PNH and the different hematologic disorders. will help deepen the diagnostic workup and enhance the theraputic potential. 
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