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Format: HTML Label: Wayne State University Press Manufacturer: Wayne State University Press Number Of Pages: 14 Publication Date: October 01, 1995 Publisher: Wayne State University Press Release Date: July 28, 2005 Studio: Wayne State University Press Browse for similar items by category: Click to Display Editorial Review: Product Description: This digital document is an article from Human Biology, published by Wayne State University Press on October 1, 1995. The length of the article is 4106 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. From the author: An extremely low production rate of a polymorphic allele (formally called the mutation rate) - a prerequisite for using the allele as a marker (particularly for anthropogenetic purposes where the alleles must be assumed to be monophyletic) - cannot be taken for granted for alleles of highly polymorphic VNTRs, but a low production rate can be used to identify alleles produced by a single nucleotide substitution. This property was indirectly tested for the [(ACT).sub.n] COL1A2 (of type I collagen) microsatellite SSTR (degree of heterozygosity H = 0.72) by searching for linkage disequilibria between the SSTR's four common alleles (n = 6, 8, 9, or 10) and three RFLPs of the same gene. A strong linkage disequilibrium between at least three of the four SSTR alleles and two of the three closely linked RFLPs has been demonstrated in a Sardinian population (Italy), a finding that suggests a low production rate of these alleles. Thus it seems that this highly polymorphic system and, by a reasonable extrapolation, other VNTRs with a comparable degree of heterozygosity may be valuable anthropogenetic markers, at least in distinguishing subgroups of a major ethnic group. Citation Details Title: Are the SSTR alleles stable enough to be considered monophyletic and hence reliable anthropogenetic markers? Linkage disequilibrium study on the (ACT)n COL1A2 SSTR. Author: G. Pepe Publication: Human Biology (Refereed) Date: October 1, 1995 Publisher: Wayne State University Press Volume: v67 Issue: n5 Page: p703(13) Distributed by Thomson Gale 
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