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by: Danielle M. Dick, Arpana Agrawal, Marc A. Schuckit, Laura Bierut, Anthony Hinrichs, Louis Fox, Joseph Mullaney, C. Robert Cloninger, Victor Hesselbrock, John I., Jr. Nurnberger, Laura Almasy, Tatiana Foroud, Bernice Porjesz, Howard Edenberg, Henri Begleiter  Availability: Available for download now
Format: HTML Label: Thomson Gale Manufacturer: Thomson Gale Number Of Pages: 26 Publication Date: March 01, 2006 Publisher: Thomson Gale Release Date: March 07, 2006 Studio: Thomson Gale Browse for similar items by category: Click to Display Editorial Review: Product Description: This digital document is an article from Journal of Studies on Alcohol, published by Thomson Gale on March 1, 2006. The length of the article is 7760 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. From the author: Objective: The gene GABRA2 has been associated with the risk for alcohol dependence in independent samples. This article explores how this genetic risk factor interacts with marital status, another factor previously shown to be associated with the risk for alcohol dependence. Method: Data from more than 1,900 male and female subjects from the Collaborative Study of the Genetics of Alcoholism (COGA) sample were analyzed. Subjects were recruited based on membership in a family with multiple individuals with alcoholism. A series of analyses was performed to evaluate the relationship between the following: (1) GABRA2 and alcohol dependence, (2) marital status and alcohol dependence, (3) GABRA2 and marital status, and (4) interactions between GABRA2 and marital status on the development of alcohol dependence in the high-risk COGA sample. Additional analyses were carried out in a sample of ~900 individuals from control families to test the generalizability of results. Results: Both GABRA2 and marital status contributed independently to the development of alcohol dependence in the COGA sample. The high-risk genotype at GABRA2 was also related to a decreased likelihood of marrying and an increased likelihood of divorce, which appeared to be mediated in part by personality characteristics. There was also differential risk associated with the GABRA2 genotype according to marital status. Conclusions: These analyses provide evidence of both gene-environment correlation and gene-environment interaction associated with GABRA2, marital status, and alcohol dependence. They illustrate the complex pathways by which genotype and environmental risk factors act and interact to influence alcohol dependence and challenge traditional conceptualizations of "environmental" risk factors. Citation Details Title: Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction *. Author: Danielle M. Dick Publication: Journal of Studies on Alcohol (Magazine/Journal) Date: March 1, 2006 Publisher: Thomson Gale Volume: 67 Issue: 2 Page: 185(10) Distributed by Thomson Gale 
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